It would be perfectly fine to attempt this with monkeys though...

Here's a warning screen that appears when you boot up the classic Habitrail Hamster Ball for the PS2. I don't remember seeing a similar screen preceding 50 Cent: Bulletproof.

"This game is purely fictional fun and in no way represents the proper treatment of real hamsters. Refer to our Hamster Care Guide on how to look after your hamster."